L-carnitine (LC) is an essential nutrient. It has vitamin-like qualities and it is considered essential in helping to transport fatty acids into mitochondria. The benefit effect of L-carnitine is proposed for treatment of obesity as long time periods. The objective of this study was to determine the effects of supplementation of LC on serum parameters in alloxaninduced diabetic rats. The animals were made diabetic using by alloxan (120 mg/kg, i.p.). The LC at doses 7, 14 and 28 mg/kg were administered for 16 days, intraperitoneally. Blood samples were obtained from heart after 16 days. The group of control diabetic rats was administered saline as vehicle. Serum glucose, cholesterol, triglycerides, LDL, HDL, urea, uric acid, creatinine, alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) enzymes levels were measured by kit. The results showed the LC treatment decreased raise of serum glucose, cholesterol, triglycerides, LDL, urea, uric acid, ALT and AST levels, while increased serum HDL level in alloxan-induced diabetic rats compared to saline control diabetic rats. The present data indicated that LC has anti-diabetic effect on diabetic animals. So, it should be considered in future therapeutic researches.
کلید واژگان :L-carnitine, diabetes, rat, alloxan
ارزش ریالی : 300000 ریال
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