Background:The development of hemolytic alloantibodies and erythrocyte autoantibodies complicates transfusion therapy in thalassemia patients. Methods: The frequency causes and prevention of this phenomenon in 90 transfused thalassemia patients were evaluated in Fatemeh Zahra Hospital in Bushehr in a cross-sectional study. Results:In our study the age of onset of symptoms ranged from 40 days to 12 years (1.72±1.88 years), the mean age at the initiation of transfusion was 2.14± 2.40 years and mean interval of transfusion was 21.88±12.53 days. Hb levels per transfusion in these patients were 8.40±0.82 %. Red cell alloantibodies were detected in 9 patients (10%). The red cell antibodies developed in this report were mainly Kell and C system. Our data showed that alloimmunization to minor erythrocyte antigens and erythrocyte autoimmunization of significant clinical variables are frequent findings in transfused thalassemia patients. Conclusion:There is no relation between the number of blood units transfused and antibody formation in thalassemia, but it is an important factor for increased alloimmunization in these patients.
کلید واژگان :antibody screening, thalassemia major, alloantibodies, autoantibodies
ارزش ریالی : 600000 ریال
با پرداخت الکترونیک