tTaenia multiceps is a globally distributed zoonotic cestode, which uses canids as definitive and the ungu-lates, especially sheep and goats as intermediate hosts. The resulting cerebral and non-cerebral cystscaused by the larval forms of this cestode are commonly known as coenurosis. The location of cyst(s)outside the central nervous system, particularly in goats, suggests that they may be a different strainor genetic variants of T. multiceps or may reflect a different host response to the parasite in the goats.Therefore, conflicting views exist on their specification and based on typological grounds, T. multiceps andTaenia gaigeri have been recognized separately. In the present study, central nervous system, muscles,heart, lungs, kidneys and other visceral organs of the experimentally infected sheep and goats, chal-lenged with T. multiceps eggs originated from the cerebral cysts, were evaluated by histopathologicaland molecular methods. Although acute and chronic forms of cerebral coenurosis were developed inthe experimentally infected sheep, non-cerebral chronic coenurosis was observed in the experimentallyinfected goats. In addition, sequence analysis using the cytochrome c oxidase subunit 1 (cox1) and NADHdehydrogenase 1 (nad1) genes of mitochondrial DNA, showed that all cerebral and non-cerebral samplesobtained from experimental infection were 100% identical to each other and their original source. Basedon molecular assessment, pathogenesis and morphological criteria the larval forms of T. multiceps werefound originated from the same species. Therefore T. gaigeri may not be a distinct species from T. multicepsand T. multiceps is a single valid species within the genus Taenia.
کلید واژگان :Coenurosis, Cox1, Nad1, Taenia multiceps
ارزش ریالی : 600000 ریال
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