This study was aimed to measure the solubility of carvedilol in the temperature and pressure
ranges of 308-338 K and 160 to 400 bar, respectively. In this direction, a homemade high
pressure visual equilibrium cell was used to measure the solubility of carvedilol using a static
method coupled with gravimetric technique. The results revealed that the carvedilol solubility
was ranged between 1.12×10-5 and 5.01×10-3 based on the mole fraction (mole of
carvedilol/mole of carvedilol + mole of CO2) in this study as the temperature and pressure
was changed. Finally, the results were correlated using four density-based semi-empirical
correlations including Chrastil, Mendez Santiago- Teja (MST), Bartle et al., and Kumar and
Johnston (K-J) models. Results revealed that although the K-J model leads to the lowest
average absolute relative deviation percent (AARD %) of 6.27 %, but it could not be
considered as the most accurate correlation since all the used four correlations introduces
AARD % of about 6-10 % which may be in the same range as the experimental error.
