Tendency to utilize Ephedra contain product are increasing due to its favorable properties such as energetic, fat burning, decongestant etc. Present of cardiovascular agonism " and $ adrenergic compound and lack of systematic research on this issue, we conduct this study to determine the Ephedra major Host. The present work aimed to study the effect of hydroethanolic extract of Ephedra major plant on vascular system and its mechanism of action. Isolated aorta from 48 male Wistar rats (Body weight 220±30 g) were tested in organ bath. Rats were anesthetized and aorta isolated and placed in Krebs-Ringer bicarbonate solution continuously bubbled with 95% O and %5 CO Carbogene then cut into ring segment 4mm in width which then 2 2 mounted in organ bath and contractive response recorded in 8 groups. Statistical compression made by student T test and ANOVA (SPSS Ver.19). A P value of =0.05 was considered as statically significant. Half Maximal Effective concentration calculated by Lab Chart Ver.7 software. The result were shown E. major extract have constriction effect on rat aorta.The Contractile mechanism, wasn't only through agonistic adrenergic mechanism of aorta induced by extract is releasing internal calcium sources mediated by metabotropic G protein. This constriction effects is due to a adrenergic agonistic mechanism accompanied with other possible mechanisms including depolarizing the calcium channels or by mediating the release of vasoconstrictive agent and or inhibition the release of endothelium relaxant.
کلید واژگان :Ephedra Herb % Vasoconstrictor % "-Blocker % Terazosin % Yohimbine
ارزش ریالی : 300000 ریال
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