To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptible animals, was used. Proteolipid protein (PLP) , which is a prominent neu[oantigen, was extracted from fresh bovine brain, and used for inducing EAE in female Balb/e and Guinea pig. Animals were weighed and examined daily for clinical symptoms. Also histological sections from EAE brains were prepared. These sections showed infiltration, congestion and demyelination
کلید واژگان :Multiple Sclerosis disease, EAE animal model, PLP
ارزش ریالی : 600000 ریال
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جزئیات مقاله
- کد شناسه : 2150771314615065
- سال انتشار : 2003
- نوع مقاله : پذیرفته شده در مجلات Scopus ,ISI, با IF=0
- زبان : انگلیسی
- محل پذیرش : Medical Journal of tne Islamic Republic oflran
- برگزار کنندگان :
- ISSN : 2251-6840
- تاریخ ثبت : 1396/07/19 12:42:26
- ثبت کننده : محمد حسین صنعتی
- تعداد بازدید : 190
- تعداد فروش : 0