Glycyrrhiza glabra is a traditional medicinal herb and the root of
plant contains several active constituents. Two major constituents
are glycyrrhizin and glycyrrhetinic acid that have a numerous
pharmacological effects. The aim of study was to evaluate anti-
Candida activity of G.glabra against vulvovaginal isolates of
Candida. Minimal inhibitory concentration of the methanolic and
ethanolic extracts was respectively 2% and <2%. Mean MICs of
ethanolic extract diluted with DW, ethanol and DMSO were
respectively 10 mg/ml, 625μg/ml and 312μg/ml. Our results
indicate potential use of G.glabra root as anti-Candida agent
isolated from vaginal candidiasis, deserving further investigation for
clinical applications.
