Isolation of fungal agents from burn wounds and determining their susceptibility to antifungal drugs

Introduction and Objectives: Burning wound provides a proper environment for growth of infectious agents. These infections have been known as the cause of more than 50% of deaths by burning. Saprophytic fungi are the most important causative agents. The aim of this study reviews the causes of fungal infections and determining their susceptibility to antifungal drugs in patients with burn injuries. Materials and Methods: In the present study 104 patients hospitalized due to burns in Taleghani hospital of Ahvaz were sampled. All samples were cultured on the Sabouraud dextrose agar containing chloramphenicole. Fungal agents were detected using morphology, microscopic appearance and additional tests for the detection of yeasts. Determination of drug sensitivity was done with disk diffusion method and sensitivity to common antifungal agents determined. Results: In our study fungal agents were detected in 15 cases (14. 42%). Fungi isolated from these patients, including Candida albicans 6 cases (40%), C. glabrata 2 cases (13. 33%), Aspergillus niger 2 cases (13. 33%), C. dubliniensis, A. fumigatus, A. flavus, Penicillium, and Mucor each one 1 case (6. 66%). Children with 13 cases (66. 66%) had the most cases of infection. Of fungal drug resistance, the isolated fungi were one hundred percent resistant to fluconazole. The greatest sensitivity respectively to clotrimazole (46. 6%), terbinafine (33. 33%), miconazole (26. 66%) and nystatin (20%) was observed. Conclusion: Recurring infections in each hospital to identify relevant studies of drug resistance and completely done until positive step in the direction taken to hospital infection control.

Burning, Fungal agents, Antifungal sensitivity