Infection with human papiloma virus (HPV) is the most frequent sexually transmitted disease worldwide.
HPV types 16, 18, 31 and 33 are considered as the most important types in the cervical cancer.This study
was undertaken on 64 samples of archival cervical carcinoma pathologic to assess the rate of HPV
infection (HPV16,18) in cervical carcinoma among Iranian patients. HPV DNA was detected by
polymerase chain reaction (PCR) and typing by restriction fragment length polymorphism (RFLP)
analysis.The total prevalence of HPV in this study (HPV16,18) for all cases was 59.4% (38/64). HPV
type 16 was the most common one (22/64, 34%) followed by HPV type 18 (16/64, 25%). On the basis of
the rate of HPV (16,18) which were detected in squamous cell carcinoma and adenocarcinoma,only
women with HPV18 infection showed a statistically significant risk for development of cervical cancer
(P=0.019) while P value for HPV16 was 0.47 .
