Frequent use of triarylmethane and its derivatives inmany drugsmakes the investigation of specific and non-specific interactions and spatial configuration of these materials in their pharmaceutical behavior, very important. Therefore, in this paper absorption and fluorescence spectra of two triarylmethane drugs (E133 and E143) were studied in different solvents. The solute's photo-physical behavior depends strongly on the solvent–solute interactions and solvent's nature, alongwith attached groups on triphenylmethane skeleton in solventmedia. In order to understand the effect of intermolecular and intramolecular interactions on spectral behaviors of these dyes, and to conceive the nature and extend of solvent-solute interactions, the spectral variations were analyzed via the linear solvation energy relationships concept, suggested by Kamlet and Taft. In addition, by means of solvatochromic method, ground and excited states dipole moments as well as dipole moment variations, from ground to excited states, were calculated, in different media.
کلید واژگان :Triarylmethane drug Solvent–solute interaction Linear solvation energy relationship Dipole moment Solvent polarity scale
ارزش ریالی : 1200000 ریال
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