Clinical and Laboratory Finding in Children with Leukemia: a Systematic Review

Introduction: Cancer as a chronic disease after accidents and unintentional deaths is the third cause of mortality among children aged 1 to 14 years.Leukemia is strongly affected parents and their family due to high prevalence of childhood, high felony, high cost of treatment and long hospitalization. Therefore, this systematic review was conducted to assess Clinical and laboratory finding in children with leukemia. Materials and Methods: This review study was carried out based on Broome method. The purpose of this method was to achieve the purpose of the study and to enhance the study's thoroughness and comprehension. The method is based on three steps in the search of texts, data evaluation and data analysis.The study was done by searching the search engines and scientific databases of articles include SID, researchgate, Sciencedirect, Google Scholar, Embase,elmnet, and PubMed in Persian and English.In the first stage, 37 articles were found. Of these, 23 articles related to the topic published in the last 30 years were reviewed. Results: According to the results of the studies, the history of drug use during pregnancy, family history of cancer, a history of radiation exposure, and breastfeeding were associated with incidence the cancer. Also, there was a significant relationship between the number of maternal pregnancies, parental age, parents' education and the history of contraceptive use by mother with acute leukemia in children. Conclusion: The results showed that some of the characteristics of parents can be one of the effective factors in the incidence of acute leukemia in children that awareness of these issues can be effective in preventing this disease. Recurrence is higher in the age group of less than 5 years compared to the age group of 5 to 10 years, so this age group needs more attention and follow up.

Leukemia, Cancer, Children, Children with Leukemia