The Comparison of the Effects of Two Herbal Medicines, Namely Senna and Lactulose, on Induced Acute Constipation in Rabbits

Constipation is a disease caused by various factors and results in the remaining of stools in colons, excessive water absorption by stools, hardening of stools and in case not treated degeneration of neural network inside colons and mega colons and is a common disease in small animals. The purposes of this study after the constipation was induced, it was treated by Senna in one group, Lactulose in another group and placebo in the third one. After a specified period of time, the information was analyzed and the treatment effects of Senna and Lactulose were compared. This Study is a clinical and semi blind trial and was performed on 30 rabbits with the same sex, breed, age and weight. These statistical studies states that lactulose with dose 0.2 ml in respect of per kg body weight was more effective than lactulose with dose 0.1 ml in respect of per kg body weight and placebo, and also state that Senna was more effective than lactulose (p<0.01). Whereas there were not significant statically differences between more or less dose of Senna in respect of treatment duration. These statistical analyses on vital factors showed that dose 18-22 mg of Senna could make significant changes in respiratory rate and blood factors such as PCV, RBC rate, WBC density, full and subtracted count of WBC, Neutrophil and Lymphocytes, in this group as compared with other group.

Herbal Medicines, Senna, Lactulose, Acute Constipation, Rabbits